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高峰 教授 个人主页

 行政职务 无
 联系电话 +86-22-27402697
 电子邮箱 fgao@tju.edu.cn
 办公地址 天津大学北洋园校区32号楼130房间
 专业方向 生物物理学
 主讲课程 《大学物理》、《生物物理导论》、《生物信息学导论》(研究生)
 通讯地址 天津大学理学院物理系
 邮政编码 300072

个人经历或学术经历

学习经历

1997年9月~2001年7月 天津大学理学院应用物理专业 本科
2001年9月~2004年3月 天津大学理学院生物物理专业 硕士 导师:张春霆院士
2004年3月~2007年3月 天津大学理学院生物物理专业 博士 导师:张春霆院士

工作经历

2007年4月~2009年6月 天津大学理学院应用物理系 讲师
2009年7月~2015年6月 天津大学理学院应用物理系 副教授
2015年7月~至今 天津大学理学院应用物理系 教授

研究方向

主要从事微生物基因组生物信息学与合成生物学研究,已在Science等刊物发表论文50篇,累积影响因子260,获Google Scholar 1220次引用(SCI引用812次)。其中,在国际知名学术刊物 (包括 PNAS, Nucleic acids research, Bioinformatics) 上发表第一(通讯)作者SCI论文35篇,SCI引用591次,被Science,Nature,Nature Biotechnology 等杂志SCI他引490次,其中7篇SCI影响因子大于7(30篇大于3),5篇单篇SCI他引大于40次,并被35本国际英文专著所引用。作为第1作者为Humana Press 出版的英文书籍撰写一个章节,作为客座主编出版专刊书籍1本。曾获中国青少年科技创新奖及全国优秀博士学位论文提名奖,入选教育部“新世纪优秀人才支持计划”、天津大学“北洋青年学者计划”和“天津市131创新型人才培养工程”。从2007年参加工作起一直从事基因组复制起始点的相关研究,系统建立和发展了细菌和古菌基因组复制起始点预测软件和数据库。其中,预测软件Ori-Finder单篇引用以及数据库DoriC累计SCI引用均过百次,作为项目负责人已连续四次获得国家自然科学基金项目资助,研究成果获Science等期刊论文印证。

科研项目、成果专利

正在承担项目: 

1. 主持国家自然科学基金(面上基金),项目名称为“酿酒酵母全基因组复制起始点的系统化分析及识别”(项目编号:31571358),资助经费57万元(直接经费),执行期限为2016.1-2019.12,负责人。



已完成项目:

1. 主持国家自然科学基金(科学部主任基金),项目名称为“真核生物全基因组范围复制起始点的预测”(项目编号:10747150),资助经费2万元,执行期限为2008.1-2008.12,负责人,已结题。
2. 主持国家自然科学基金(青年基金),项目名称为“微生物基因组复制起始区的系统化识别及功能性分析”(项目编号:30800642),资助经费16万元,执行期限为2009.1-2011.12,负责人,已结题。
3. 主持国家自然科学基金(面上基金),项目名称为“上千种细菌基因组复制起始区的规律提取及应用”(项目编号:31171238),资助经费60万元,执行期限为2012.1-2015.12,负责人。
4. 主持教育部新世纪优秀人才支持计划项目(项目编号:NCET-12-0396),资助经费50 万元,执行期限为2013.1-2015.12,负责人。
5. 参加国家自然基金(重大研究项目),项目名称为“人与其它高等真核生物全基因组中的Isochore结构研究” (项目编号:90408028),资助经费40万元,执行期限为2005.1-2007.12,主要参与人,已结题。

论文专著

ResearcherID URL: http://www.researcherid.com/rid/C-9913-2009
ORCID: http://orcid.org/0000-0002-9563-3841
Google scholar http://scholar.google.com/citations?user=_jqaatIAAAAJ&hl=en

Publication as Corresponding Author:

1. Huang, H, Yang, Z-L, Wu, X-M, Wang, Y, Liu, Y-J, Luo, H, Lv, X, Gan, Y-R, Song, S-D, Gao, F*: Complete genome sequence of Acinetobacter baumannii MDR-TJ and insights into its mechanism of antibiotic resistance. Journal of Antimicrobial Chemotherapy 2012, 67(12):2825-2832.
2. Gao, F*, Luo, H, Zhang, C-T*: DoriC 5.0: an updated database of oriC regions in both bacterial and archaeal genomes. Nucleic Acids Research 2013, 41(D1):D90-D93.
3. Gao, F*: Recent Advances in the identification of replication origins based on the Z-curve method. Current Genomics 2014, 15(2):104-112.
4. Huang, H, Dong, Y, Yang, ZL, Luo, H, Zhang, X, Gao, F*: Complete sequence of pABTJ2, a plasmid from Acinetobacter baumannii MDR-TJ, carrying many phage-like elements. Genomics, Proteomics & Bioinformatics 2014, 12(4):172-177.
5. Luo, H, Zhang, C-T*, Gao, F*: Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes. Frontiers in Microbiology 2014, 5:482.
6. Peng, C, Gao, F*: Protein localization analysis of essential genes in prokaryotes. Scientific Reports 2014, 4:6001.
7. Gao, F*: Bacteria may have multiple replication origins. Frontiers in Microbiology 2015, 6:324.
8. Huang, H, Song, C-C, Yang, Z-L, Dong, Y, Hu, Y-Z, Gao, F*: Identification of the replication origins from Cyanothece ATCC 51142 and their interactions with the DnaA protein: from in silico to in vitro studies. Frontiers in Microbiology 2015, 6:1370.
9. Jia, N, Du, J, Ding, M-Z, Gao, F*, Yuan, Y-J*: Genome sequence of Bacillus endophyticus and analysis of its companion mechanism in the Ketogulonigenium vulgare-Bacillus strain consortium. PLoS ONE 2015, 10(8):e0135104.
10. Peng, C, Luo, H, Zhang, X, Gao, F*: Recent advances in the genome-wide study of DNA replication origins in yeast. Frontiers in Microbiology 2015, 6:117.
11. Zhang, X, Peng, C, Zhang, G, Gao, F*: Comparative analysis of essential genes in prokaryotic genomic islands. Scientific Reports 2015, 5:12561.
12. Gao, F*: Editorial: DNA replication origins in microbial genomes. Frontiers in Microbiology 2016, 6:1545.
13. Jia, N, Ding, M-Z*, Du, J, Pan, C-H, Tian, G, Lang, J-D, Fang, J-H, Gao, F*, Yuan, Y-J: Insights into mutualism mechanism and versatile metabolism of Ketogulonicigenium vulgare Hbe602 based on comparative genomics and metabolomics studies. Scientific Reports 2016, 6:23068.
14. Jia, N, Ding, M-Z*, Gao, F*, Yuan, Y-J: Comparative genomics analysis of the companion mechanisms of Bacillus thuringiensis Bc601 and Bacillus endophyticus Hbe603 in bacterial consortium. Scientific Reports 2016, 6:28794.
15. Jia, N, Ding, M-Z*, Du, Y-Z, Feng, S, Gao, F*, Yuan, Y-J: Complete genome sequence of the industrial bacterium Ketogulonicigenium vulgare SKV. Genome Announc 2016, 4(6):e01426-16.
16. Jia, N, Ding, M-Z*, Luo, H, Gao, F*, Yuan, Y-J: Complete genome sequencing and antibiotics biosynthesis analysis of Streptomyces lydicus 103. Scientific Reports 2017, 7:44786.
17. Jia, N, Ding, M-Z*, Zou, Y, Gao, F*, Yuan, Y-J: Comparative genomics and metabolomics analyses of the adaptation mechanism in Ketogulonicigenium vulgare-Bacillus thuringiensis consortium. Scientific Reports 2017, 7:46759.
18. Zhang, G, Gao, F*: Quantitative analysis of correlation between AT and GC biases among bacterial genomes. PLoS ONE 2017, 12(2):e0171408.
19. Peng, C, Lin, Y, Luo, H and Gao, F*: A comprehensive overview of online resources to identify and predict bacterial essential genes. Frontiers in Microbiology 2017, 8:2331.
20. Yang, Z-K, Gao, F*: The systematic analysis of ultraconserved genomic regions in the budding yeast. Bioinformatics 2018, 34(3):361-366.
21. Luo, H, Quan, C-L, Peng, C and Gao, F*: Recent development of Ori-Finder system and DoriC database for microbial replication origins. Briefings in Bioinformatics 2018, doi: 10.1093/bib/bbx174.
22. Gao, F*: Recent developments of software and database in microbial genomics and functional genomics. Briefings in Bioinformatics 2018, doi: 10.1093/bib/bby013.

Publication as First Author:

1. Gao, F, Ou, H-Y, Chen, L-L, Zheng, W-X, Zhang, C-T: Prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing SARS-CoV genomes. FEBS Letters 2003, 553(3):451-456.
2. Gao, F, Zhang, C-T: Comparison of various algorithms for recognizing short coding sequences of human genes. Bioinformatics 2004, 20(5):673-681.
3. Gao, F, Zhang, C-T: GC-Profile: a web-based tool for visualizing and analyzing the variation of GC content in genomic sequences. Nucleic Acids Research 2006, 34(W1):W686-W691.
4. Gao, F, Zhang, C-T: Isochore structures in the chicken genome. FEBS Journal 2006, 273(8):1637-1648.
5. Gao, F, Zhang, C-T: DoriC: a database of oriC regions in bacterial genomes. Bioinformatics 2007, 23(14):1866-1867.
6. Gao, F, Zhang, C-T: Origins of replication in Cyanothece 51142. Proc Natl Acad Sci USA 2008, 105(52):E125.
7. Gao, F, Zhang, C-T: Prediction of replication time zones at single nucleotide resolution in the human genome. FEBS Letters 2008, 582(16):2441-2444.
8. Gao, F, Zhang, C-T: Origins of replication in Sorangium cellulosum and Microcystis aeruginosa. DNA Research 2008, 15(3):169-171.
9. Gao, F, Zhang, C-T: Ori-Finder: A web-based system for finding oriCs in unannotated bacterial genomes. BMC Bioinformatics 2008, 9:79.
10. Gao, F, Wang, Y, Liu, Y-J, Wu, X-M, Lv, X, Gan, Y-R, Song, S-D, Huang, H: Genome Sequence of Acinetobacter baumannii MDR-TJ. Journal of Bacteriology 2011, 193(9):2365-2366.
11. Gao, F, Zhang, RR: Enzymes are enriched in bacterial essential genes. PLoS ONE 2011, 6(6):e21683.
12. Gao, F#, Lin, Y#, Zhang, RR: RNA-DNA differences are rarer in proto-oncogenes than in tumor suppressor genes. Scientific Reports 2012, 2:245 (#These authors contributed equally to this work).
13. Gao, F, Luo, H, Zhang, C-T: DeOri: a database of eukaryotic DNA replication origins. Bioinformatics 2012, 28(11):1551-1552.
14. Gao, F, Luo, H, Fu, Z, Zhang, C-T, Zhang, R: Exome sequencing identifies novel ApoB loss-of-function mutations causing hypobetalipoproteinemia in type 1 diabetes. Acta Diabetologica 2015, 52(3):531-537.
15. Wei, W#, Gao, F#, Du, M-Z, Hua, H-L, Wang, J, Guo, F-B: Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties. Briefings in Bioinformatics 2017, 18(3):357-366 (#These authors contributed equally to this work).

Other Publication:

1. Chen, L-L, Gao, F: Detection of nucleolar organizer and mitochondrial DNA insertion regions based on the isochore map of Arabidopsis thaliana. FEBS Journal 2005, 272(13):3328-3336.
2. Zhang, C-T, Gao, F, Zhang, R: Segmentation algorithm for DNA sequences. Physical Review E 2005, 72(4):041917.
3. Zheng, W-X, Chen, L-L, Ou, H-Y, Gao, F, Zhang, C-T: Coronavirus phylogeny based on a geometric approach. Molecular Phylogenetics and Evolution 2005, 36(2):224-232.
4. Lin, Y, Gao, F, Zhang, C-T: Functionality of essential genes drives gene strand-bias in bacterial genomes. Biochemical and Biophysical Research Communications 2010, 396(2):472-476.
5. Yang, Z-G, Gao, F, Zhang, C-T: Comparison of Journal Self-Citation Rates between Some Chinese and Non-Chinese International Journals. PLoS ONE 2012, 7(11):e49001.
6. Zhang, R, Yao, F, Gao, F, Abou-Samra, AB: Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. PLoS ONE 2012, 7(9):e46254.
7. Luo, H, Lin, Y, Gao, F, Zhang, C-T, Zhang, R: DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements. Nucleic Acids Research 2014, 42(D1):D574-D580.
8. Zhang, R, Ou, H-Y, Gao, F, Luo, H: Identification of horizontally-transferred genomic islands and genome segmentation points by using the GC profile method. Current Genomics 2014, 15(2):113-121.
9. Luo, H, Gao, F, Lin, Y: Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes. Scientific Reports 2015, 5:13210.
10. Zhang, C, Gao, F, Luo, H, Zhang, C-T, Zhang, R: Differential response in levels of high-density lipoprotein cholesterol to one-year metformin treatment in prediabetic patients by race/ethnicity. Cardiovascular Diabetology 2015, 14(1):79.
11. Zhang, C, Luo, H, Gao, F, Zhang, C-T, Zhang, R: A reduction in both visceral and subcutaneous fats contributes to increased adiponectin by lifestyle intervention in the Diabetes Prevention Program. Acta Diabetologica 2015, 52(3):625-628.
12. Wu, Y, Li, B-Z, Zhao, M, Mitchell, LA, Xie, Z-X, Lin, Q-H, Wang, X, Xiao, W-H, Wang, Y, Zhou, X, Liu, H, Li, X, Ding, M-Z, Liu, D, Zhang, L, Liu, B-L, Wu, X-L, Li, F-F, Dong, X-T, Jia, B, Zhang, W-Z, Jiang, G-Z, Liu, Y, Bai, X, Song, T-Q, Chen, Y, Zhou, S-J, Zhu, R-Y, Gao F, Kuang, Z, Wang, X, Shen, M, Yang, K, Stracquadanio, G, Richardson, SM, Lin, Y, Wang, L, Walker, R, Luo, Y, Ma, P-S, Yang, H, Cai, Y, Dai, J, Bader, JS, Boeke, JD, and Yuan, Y-J: Bug mapping and fitness testing of chemically synthesized chromosome X. Science 2017, 355(6329): eaaf4706.
13. Xu, XJ, Hao, LL, Zhu, JW, Zhou, Q, Song, FH, Chen, TT, Zhang, SS, Dong, LL, Lan, L, Wang, YQ, Liang, F, Cao, JB, Liu, F, Liu, L, Wang, F, Ma, YK, Zhang, LJ, Chen, ML, Tian, DM, Li, CP, Du, ZL, Yuan, N, Zeng, JY, Zhang, ZW, Wang, JY, Shi, S, Zhang, YD, Pan, MY, Tang, BX, Zou, D, Song, SH, Sang, J, Xia, L, Wang, ZN, Li, M, Niu, GY, Zhang, Y, Sheng, X, Lu, MM, Wang, Q, Liang, F, Li, MW, Sun, SX, Li, RJ, Yu, CL, Wang, GY, Li, M, Yin, HY, Ma, LN, Chen, HX, Sun, YB, Yu, L, Zhai, S, Sun, MY, Zhang, Z, Zhao, WM, Xiao, JF, Bao, YM, Song, SH, Miao, YR, Guo, AY, Lin, SF, Xue, Y, Luo, H, Gao, F, Ma, W, Cui, QH, Xu, HD: Database resources of the BIG Data Center in 2018. Nucleic Acids Res 2018, 46(Database issue):D14-D20.

书籍

1 .Gao, F, Luo, H, Zhang, C-T, Zhang, R: Gene essentiality analysis based on DEG 10, an updated database of essential genes. Methods in molecular biology (Clifton, NJ) 2015, 1279:219-233.
2. Gao, F ed.: DNA replication origins in microbial genomes. Lausanne: Frontiers Media 2016, doi: 10.3389/978-2-88919-779-8.

奖励、荣誉和学术兼职

曾获中国青少年科技创新奖,全国优秀博士学位论文提名奖,受苏黎世联邦理工学院教授 Ruedi Aebersold 和美国国立人类基因组研究所主任Eric Green 邀请加入 Faculty of 1000 (F1000Prime: FACULTY MEMBER),入选教育部“新世纪优秀人才支持计划”,“天津市131创新型人才培养工程”(第二层次人选) 和天津大学“北洋青年学者计划”。担任Frontiers in Microbiology、Frontiers in Genetics 杂志(SCI二区刊物)副主编,Briefings in Bioinformatics (SCI一区刊物),Scientific Reports (SCI三区刊物),PLoS ONE (SCI三区刊物), Genomics Proteomics & Bioinformatics (新晋SCI刊物)杂志编委,Briefings in Bioinformatics (主持专刊 Recent developments of software and database in microbial genomics and functional genomics)和Frontiers in Microbiology (主持专刊 DNA Replication Origins in Microbial Genomes 及其 2nd Edition)客座主编。担任了教育部科技奖励、教育部学位与研究生教育发展中心学科评估(第四轮)、国家自然科学基金通讯评审专家,国家重点研发计划生物安全重点专项预算终评专家,中国细胞生物学学会功能基因组信息学与系统生物学分会理事,中国遗传学会生物大数据专业委员会委员,中国医药生物技术协会生物医学信息技术分委会委员,中国计算机学会计算机应用专业委员会通信委员等。担任Bioinformatics, Briefings in Bioinformatics, Molecular Therapy-Nucleic Acids,Information Sciences, Journal of Antimicrobial Chemotherapy, Antimicrobial Agents and Chemotherapy 等二十余个SCI刊物的审稿人。

指导研究生情况

目前指导博士生3名,硕士生3名。

天津大学生物信息中心(主页 http://tubic.tju.edu.cn)欢迎有物理学、计算机、分子生物学、数学背景的同学前来报考。

(最后更新于2018-04-02 11:16:49)